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[Raymondtags]

Writer takes art lovers on a literary climb

Audubon Society's Wild Arts Festival lets nature weave its artistic story

Two years ago, Peter Zuckerman left his job and boarded a plane to Nepal, intrigued by a news story he read about a disaster on the world most dangerous climbing peak, pandora 2016 K2.

The North Portland 32 year old (who happens to be Mayor Sam Adams domestic partner) took the plane as far as it would go, then a jeep as far as it would go, and walked for several weeks to reach his destination: a remote village where the language is so unique, it pandora 2016 required two translators to communicate.

ask, old are you, and there was a discussion between the translators and his interview subject, Zuckerman recalls. His subject answered, it went through both translators again, then he would say, was born in the winter during this festival of the Buddha.

It was the ultimate test in cultural differences pandora charms deals and communication.

hung out for a week until they got comfortable talking to me, he says, then they said the person I was looking for was in another village.

Somehow, Zuckerman and his cousin, Amanda Padoan, were able pandora jewelry outlet to collect stories of the sherpas during a total of seven trips to Nepal, and spend the next year and a half writing his second book, in the Sky: The Extraordinary Story of the Sherpa Climbers on pandora jewelry 70% off clearance K2 Deadliest Day.

Since its release in June, the book has landed on bestseller lists and has been racking up the accolades, including the 2012 George Orwell Award for Distinguished Contribution to Honesty and Clarity in Public Language, as well as the Banff Mountain Film and Book Festival 2012 Mountaineering Award.

The festival on Nov. In addition to paintings, other media include photography, glass, watercolors, jewelry and woodwork, among others.

Other mainstays at the annual event are the Wild Art Project with local art for $40, a silent auction with more than 100 items, and Audubon educational birds for kids.

Next stop Malawi?

Since the release of in the Sky, Zuckerman has been overwhelmed by the reaction to the book especially since it began as a harebrained idea. Embassy told you to stay away from, you don have a publisher and you quitting your job to do this.

Zuckerman, a Los Angeles native who moved to Portland and met Sam Adams months before Adams was elected to office in 2008, had written about Clackamas County for The Oregonian.

He had also racked up prestigious awards for pandora sale his investigative reporting at the Idaho Falls Post Register, where he broke national news about the Boy Scouts molestation scandal.

As Zuckerman and Padoan returned with their research from Nepal and put together a book proposal, they still didn know if anyone would go for it, Zuckerman says.

was sort of like eBay nobody really interested until the last hour, and then tons of people jump in, he says.

They were able to find an agent and publisher, and continue the work all with Adams support. The couple registered under Oregon domestic partnership last year, and Zuckerman says are good.

would be nice to someday have the freedom to marry in Oregon, he says.

When Adams ends his term in office in January, Zuckerman isn quite sure how their life will change: sort of hard to imagine it because it so busy right now.

Zuckerman says he will invite Adams on his next adventure, wherever it may be. One idea is set in the African nation of Malawi, where a same sex couple was having an engagement ceremony in their backyard.

raid it, send them to jail, sentence them to the equivalent of death, he says.

It was 2009 and Madonna was there, adopting her 4 year old daughter. The internationally known performer heard about the event and was horrified. Secretary of State Hilary Clinton, and the couple imprisonment became a cause celeb.

case changes how the United Nations handles foreign aid to countries, and to some extent it exposes a campaign by the religious right to push draconian anti gay laws, Zuckerman says.

In one way, Zuckerman sees it as the ultimate Romeo and Juliet story. On the other hand, he thinks of its marketability: gay people in Africa, he says. pandora jewelry outlet exactly the biography of Steve Jobs, an obvious huge seller.

Before he heads off to Africa or anywhere else, Zuckerman is keeping busy doing communications and advocacy work at Basic Rights Oregon.

He has a steady schedule of local book related events, like the Wild Arts Festival, where he tells his audiences why his book is unique in the world of true adventure stories.

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[Raymondtags]

How nickel turns on innate immune cells

Ben Roediger1 and Wolfgang Weninger1,2Nickel hypersensitivity, an example of hapten mediated allergic contact dermatitis, is one of the most prevalent allergic conditions in the Western world. Hapten mediated contact hypersensitivity results from the binding of small molecules, in this case nickel ions (Ni2 to larger proteins, thereby converting self antigens to highly immunogenic peptides when presented in the context of major histocompatibility complex (MHC) molecules. Haptens penetrating the epidermis bind to the peptide molecules of cutaneous dendritic cells (DCs), which migrate to draining lymph nodes and present the antigen to hapten specific naive T cells. These T cells are then expanded and, on reexposure, drive an inflammatory reaction within the skin. Both CD4 and CD8 Ni2 T cells can be readily detected within the blood of patients with nickel allergy and these cells secrete high levels of interferon on exposure to Ni2 in vitro.1

Initial priming and expansion of such Ni2 T cells, however, require more than simply exposure to Ni2 antigens. The natural response to neoantigens under noninflammatory conditions is generally one of tolerance, not immunity. The generation of an immunogenic response requires additional signals, for example, mediated by pattern recognition receptors, including the Toll like receptor (TLR) family. pandora charms outlet Indeed, in mice, sensitization to pandora 2016 nickel cannot be achieved without an additional adjuvant to drive the expansion of Ni2 T cells.2 In humans, however, nickel appears to function as its own adjuvant, although the mechanism by which this occurs, and the reason for the discrepancy between mice and men, has until now remained unknown. In a recent seminal study published in Nature Immunology, Schmidt et al.3 identify human, but not mouse, TLR4 as a receptor for Ni2 thereby providing an explanation not only for the immunostimulatory properties of nickel, but also for this species difference in nickel sensitization.

It has long been recognized that nickel, in addition to being a hapten, is capable of independently provoking an inflammatory response. They then used this species discrepancy to narrow the region of TLR4 involved in Ni2 signaling to amino acid positions 369 From these data and structural modeling, nickel was then predicted to bind two nonconserved histidine residues (His456 and His458) pandora 2016 within this region, and this was subsequently confirmed by mutagenesis experiments. Importantly, binding of the natural TLR4 ligand lipopolysaccharide was intact in the His456 mutants, indicating distinct structural binding characteristics. They demonstrated that nickel sensitization in these mice could be achieved without a further requirement for adjuvant, in contrast to wild type mice or transgenic mice expressing mouse TLR4. Although it remains possible that Ni2 directly binds to other TLRs, these results nevertheless clearly show that Ni2 directly binds to human TLR4 and that this is sufficient for nickel sensitization. Thus, one can envisage a scenario of nickel sensitization in which skin DCs become activated by Ni2 pandora charms sale through TLR4 such that they effectively prime Ni2 T cells within draining pandora sale lymph nodes (Figure 1). It is worth noting that human Langerhans cells (LCs), the primary DC subset within the epidermis, are unlikely to be involved in this process, as they do not express TLR4.7 Rather, the deeper dermal DCs, which differ phenotypically and functionally from LCs, appear to be better candidates as initiators of nickel sensitization. jewelry) and gain access to dendritic cells (DCs) within the skin. These pandora jewelry 70% off clearance nickel ions then bind to MHC peptide complexes as well as activating DCs through TLR4 mediated NF translocation. Activated DCs then migrate to skin draining lymph nodes where they prime nickel specific T cells. It is these T cells that then mediate the hypersensitivity pandora outlet response on reexposure of the skin to nickel.

Full figure and legend (106K)

In light of these results, it is remarkable that not more of us are sensitive to nickel. Other haptens that induce an independent inflammatory reaction, such as urushiol in poison ivy, are exceedingly effective at generating contact hypersensitivity. However, even including the large number of affected individuals, the majority of us do not react to nickel, despite the near ubiquitous presence nickel in our environment. Clearly, many factors influence our immunological response to nickel, with tolerance prevailing the majority of the time. How these regulatory mechanisms break down in affected individuals remains a mystery, but their elucidation will provide the basis for future prevention strategies. In this respect, it is noteworthy that the human TLR4 transgenic mouse generated by Schmidt et al. can be used as a suitable model of nickel sensitivity, without the requirement for strong adjuvants that override important regulatory processes present in more physiological settings.

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[Raymondtags]

Jessica Lowndes and Kellan Lutz party at Tao

The Yugoslavia born 22 year old, whose new career has been boosted by Jay Z, arrived on the red carpet in a floral print Kye dress, Ferragamo boots and jewelry by Ambush and posed for photographs for photographers and fans.

Ora, who has a mezzo soprano range, dined with friends at the popular and uber successful Asian restaurant before making her way upstairs to the hotspot led by DJ Five the night before Easter. The group had a VIP booth overlooking the dance floor, and Ora was mesmerized by the Bottle Fairy. Before her night was over, Ora took to the stage and performed her hits "Radioactive" and "RIP."

Also at Tao: gorgeous "90210" starlet Jessica Lowndes, who stopped by Ora's table in the dining room to say hello to the singer, who once guest starred on The CW series. Lowndes and friends, including new boyfriend model and ex rugby player Thom Evans, enjoyed dinner before heading to the nightclub, where they had celebratory shots in honor of Thom's 28th birthday on Tuesday. Before Tao, Lowndes spent the afternoon under the sun at Tao Beach.

"Twilight" stud Kellan Lutz treated his father Brad Lutz to a birthday dinner at Tao. judge Tulisa Contostavlos with friends at a VIP table. Buckley treated his fiancee Abigail Ochse to a birthday dinner before the happy couple made their way to Tao. Thanks to Brenton Ho of Powers Imagery for his photo gallery of Ora and Lowndes.

Don Chareunsy is editor of Vegas DeLuxe and senior editor for arts and entertainment of the Las Vegas Sun.

Robin Leach has been a journalist for more than 50 years and has spent the past decade giving readers the inside scoop on Las Vegas, the world's premier platinum playground.

Venetian Resort Hotel Casino In the spirit of Venice, The Venetian is a little piece of romantic Italy right here in Las Vegas. The Venetian is an "all suite" hotel, with rooms accented with plush linens and Italian marble. The 4,027 suites are divided into two towers: The 36 story Venetian Tower that offers guests a taste of luxurious Las Vegas and the Venezia suites, which guarantee 12 floors of high end elegance. The top five floors are the hotel's highest level of luxury with its private pandora uk sale access, concierge lounge, upgraded features and even a dedicated staff.

Entertainment at the Venetian includes shows such as Tim and Faith Soul2Soul, pandora charms sale clearance featuring Tim McGraw and Faith Hill, and Rock of Ages.

The flagship of Venetian nightlife is TAO, an ultra hip nightclub located inside of TAO Asian Bistro. V Bar is The Venetian's super smooth ultra lounge, made pandora 2016 by the owners of New York City's club Lotus and Los Angeles' super swank Sunset Room.

The Venetian features 19 restaurants including Thomas Keller's award winning French restaurant pandora jewelry clearance Bouchon, Mario Batali's B Ristorante, Aquaknox for fresh seafood and the 42,000 square foot TAO Asian Bistro. There's also the food court inside the Canal Shoppes for those looking for a quick bite.

Guests can float along The Grand Canal Shops in an authentic Italian gondola ride and pass stores like Burberry and Kenneth Cole along the way. And if you haven't caught a real celeb, on the street pandor bracelets in Vegas, you can head over to Madame Tussauds to check out a wax version.

NV 89109Tao Unless you've been in a coma or are a Miss pandora outlet Havasham esque recluse, you've probably heard of Tao and its spectacular food and ambiance. Beating out world famous New York favorite Tavern on the Green for highest grossing restaurant, Tao pandora jewelry clearance will pleasure every one of your senses with Chinese, Japanese and Thai cuisine served in a beautiful eastern influenced setting that features waterfalls, century old woods and stones, a hand carved 20 foot tall Buddha and an infinity pool full of Japanese carp. Tao's entertainment complex also includes an ultralounge, nightclub, and rooftop pool, and although it sprawls about 42,000 feet, is often packed with wall to wall people. 3355 S.

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